- HUGHES, HUGH MICHAEL (1858 - 1933), Independent minister
- HUGHES, HUGH PRICE (1847 - 1902), Wesleyan Methodist minister
- HUGHES, HUGH ROBERT (1827 - 1911) Kinmel, Dinorben,, genealogist
- HUGHES, HYWEL STANFORD (1886 - 1970), cattle breeder, benefactor and Welsh nationalist
- HUGHES, ISAAC (Craigfryn; 1852 - 1928), novelist
- HUGHES, JAMES (Iago Trichrug; 1779 - 1844), Calvinistic Methodist minister, poet, and Bible commentator
- HUGHES, JAMES BILSLAND (Iago Bencerdd; 1831 - 1878), harpist
- HUGHES, JANE (Deborah Maldwyn; 1811 - 1878), hymnist
- HUGHES, JANE MYFANWY - see EAMES, WILLIAM
- HUGHES, JOHN (1873 - 1932), composer of the hymn-tune 'Cwm Rhondda'
- HUGHES, JOHN (1896 - 1968), musician
- HUGHES, JOHN (CEIRIOG) (Ceiriog; 1832 - 1887), poet
- HUGHES, JOHN (1776 - 1843), Wesleyan minister, and antiquary
- HUGHES, JOHN (1787 - 1860), archdeacon, Evangelical cleric, and writer
- HUGHES, JOHN (1775 - 1854), Calvinistic Methodist minister, author, and hymn-writer
- HUGHES, JOHN (1827 - 1893), Calvinistic Methodist minister
- HUGHES, JOHN (1796 - 1860), Calvinistic Methodist minister and author
- HUGHES, JOHN (Glanystwyth; 1842 - 1902), Wesleyan minister
- HUGHES, JOHN (1814 - 1889), engineer and pioneer of iron-works in Russia
- HUGHES, JOHN (1850 - 1932), Calvinistic Methodist minister, author, and poet
- HUGHES, JOHN (c. 1790 - 1869), musician
- HUGHES, JOHN, physician - see HUGHES, HUGH
- HUGHES, JOHN EDWARD (1879 - 1959), minister (Presb.) and author
- HUGHES, JOHN EVAN (1865 - 1932), Calvinistic Methodist minister and editor
- HUGHES, JOHN GRUFFYDD MOELWYN (1866 - 1944), Calvinistic Methodist minister
- HUGHES, JOHN HENRY (Ieuan o Leyn; 1814 - 1893), Congregational minister and poet
- HUGHES, JOHN JAMES (Alfardd; 1842 - 1875), journalist
- HUGHES, JOHN (1615 - 1686), Jesuit
- HUGHES, JOHN RICHARD (1828 - 1893), Calvinistic Methodist minister and celebrated evangelist
- HUGHES, JOHN WILLIAM (Edeyrn ap Nudd, Edeyrn o Fôn; 1817 - 1849), a literary tramp
- HUGHES, JOHN WILLIAMS (1888 - 1979), Baptist minister and college principal
- HUGHES, JONATHAN (1721 - 1805), poet
- HUGHES, JOSEPH (Carn Ingli; 1803 - 1863), cleric and eisteddfodic poet
- HUGHES, JOSEPH TUDOR (Blegwryd; 1827 - 1841), boy harpist
- HUGHES, JOSHUA (1807 - 1889), bishop
- HUGHES, JOSHUA PRITCHARD (1847 - 1938), bishop - see HUGHES, JOSHUA
- HUGHES, LOT (1787 - 1873), Wesleyan minister and historian
- HUGHES, MARY ANNE - see LEWIS
- HUGHES, MEGAN WATTS (1842 - 1907), vocalist
- HUGHES, MICHAEL (1752 - 1825), industrialist
- HUGHES, OWEN (d. 1708), attorney
- HUGHES, OWEN (Glasgoed; 1879 - 1947), railway official, businessman and poet
- HUGHES, PRYCE (c. 1687 - 1715), American colony planner
- HUGHES, RICHARD (c. 1565 - 1619), poet
- HUGHES, RICHARD (1794 - 1871), printer and publisher
- HUGHES, RICHARD SAMUEL (1855 - 1893), musician
- HUGHES, RICHARD SAMUEL (1888 - 1952), minister (Presb.), and college tutor
- HUGHES, ROBERT (1811 - 1892), Calvinistic Methodist minister
- HUGHES, ROBERT (Robin Ddu yr Ail o Fôn; 1744 - 1785), poet
- HUGHES, ROBERT ARTHUR (1910 - 1996), medical missionary in Shillong, Meghalaya, north-east India, and an influential leader in the Presbyterian Church of Wales