- HUET, THOMAS (d. 1591), Biblical translator
- HUGHES CADFAN - see HUGHES, HUGH
- HUGHES FAWR - see HUGHES, EVAN
- HUGHES GRIFFITHS, ANNIE JANE (1873 - 1942), peace campaigner
- HUGHES, ALFRED WILLIAM (1861 - 1900), surgeon and professor
- HUGHES, ANNA MARIA - see HARRIS, JOSEPH
- HUGHES, ANNIE HARRIET (Gwyneth Vaughan; 1852 - 1910), writer
- HUGHES, ARTHUR (1878 - 1965), writer
- HUGHES, ARWEL (1909 - 1988), musician
- HUGHES, CHARLES (1823 - 1886), publisher
- HUGHES, CLEDWYN (BARON CLEDWYN OF PENRHOS), (1916 - 2001), politician
- HUGHES, DAVID (d. 1609), founder of Beaumaris grammar school
- HUGHES, DAVID (1813 - 1872), Independent minister, and author
- HUGHES, DAVID (1785 - 1850), cleric and author
- HUGHES, DAVID (Cristiolus Môn; 1810 - 1881), musician
- HUGHES, DAVID (EOS IAL; 1794? - 1862), poet and publisher
- HUGHES, DAVID (1800 - 1849), Independent minister
- HUGHES, DAVID EDWARD (1829 - 1900), physicist and inventor
- HUGHES, DAVID ROWLAND (Myfyr Eifion; 1874 - 1953), secretary of the National Eisteddfod
- HUGHES, DEWI ARWEL (1947 - 2017), Christian leader and theologian
- HUGHES, EDWARD (Y Dryw; 1772 - 1850), eisteddfodic poet
- HUGHES, EDWARD (1856 - 1925), general secretary and agent of the North Wales Miners Association
- HUGHES, EDWARD (1738 - 1815) - see HUGHES, HUGH ROBERT
- HUGHES, EDWARD (d. 1862), harpist
- HUGHES, EDWARD DAVID (1906 - 1963), scientist and Professor of Chemistry in London University
- HUGHES, EDWARD ERNEST (1877 - 1953), first Professor of history at the University College, Swansea, and a notable intermediary between the university and the public
- HUGHES, ELIZABETH PHILLIPS (1851 - 1925), educationalist
- HUGHES, ELLEN (1862 - 1927), poet, essayist, lecturer, preacher, temperance campaigner
- HUGHES, EMRYS DANIEL (1894 - 1969), politician, journalist and author
- HUGHES, EVAN (d. 1800), cleric and author
- HUGHES, EZEKIEL (1766 - 1849), one of the early Welsh settlers in the far west of the U.S.A.
- HUGHES, GAINOR (1745 - 1780), fasting woman
- HUGHES, GARETH - see HUGHES, WILLIAM JOHN
- HUGHES, GARFIELD HOPKIN (1912 - 1969), university lecturer and Welsh scholar
- HUGHES, GRIFFITH (fl. 1707-1750), cleric and naturalist
- HUGHES, GRIFFITH (1775 - 1839), Congregational minister
- HUGHES, GRIFFITH WILLIAM (1861 - 1941), accountant and musician
- HUGHES, HENRY (1841 - 1924), Calvinistic Methodist minister and historian
- HUGHES, HENRY BAILEY (1833 - 1887), Roman Catholic priest
- HUGHES, HENRY HAROLD (1864 - 1940), archaeologist
- HUGHES, HENRY MALDWYN (1875 - 1940), Wesleyan minister and theologian
- HUGHES, HOWEL HARRIS (1873 - 1956), minister (Presb.), principal of the Theological College, Aberystwyth
- HUGHES, HUGH (BRYTHON) (1848 - 1913), school-teacher and author
- HUGHES, HUGH (Huw ap Huw, Y Bardd Coch o Fôn; 1693 - 1776), gentleman and poet
- HUGHES, HUGH (1778 - 1855), Wesleyan minister
- HUGHES, HUGH (1790 - 1863), artist and author
- HUGHES, HUGH (Tegai; 1805 - 1864), Independent minister and man of letters
- HUGHES, HUGH (Cadfan Gwynedd, Hughes Cadfan; 1824 - 1898), one of the Welsh pioneers in Patagonia
- HUGHES, HUGH DERFEL (1816 - 1890), poet
- HUGHES, HUGH JOHN (1828? - 1872), author and musician