- HUGHES, ROBERT ARTHUR (1910 - 1996), medical missionary in Shillong, Meghalaya, north-east India, and an influential leader in the Presbyterian Church of Wales
- HUGHES, ROBERT GWILYM (1910 - 1997), poet and minister with the Welsh Calvinistic Methodist denomination
- HUGHES, ROBERT OWEN (Elfyn; 1858 - 1919), journalist and poet
- HUGHES, ROBERT RICHARD (1872 - 1957), minister (Presb.), and author
- HUGHES, ROWLAND (1811 - 1861), Wesleyan minister
- HUGHES, ROYSTON JOHN (BARON ISLWYN), (1925 - 2003), politician
- HUGHES, SIÂN (1811 - 1878) - see HUGHES, JANE
- HUGHES, STEPHEN (1622 - 1688), early Nonconformist
- HUGHES, T. ROWLAND - see HUGHES, THOMAS ROWLAND
- HUGHES, THOMAS (1854 - 1928), Wesleyan minister
- HUGHES, THOMAS (Glan Pherath; 1803 - 1898), Calvinistic Methodist minister
- HUGHES, THOMAS (1758 - 1828), Calvinistic Methodist minister
- HUGHES, THOMAS (1814 - 1884), Wesleyan minister
- HUGHES, THOMAS HYWEL (1875 - 1945), Congregational minister, theologian, and philosopher
- HUGHES, THOMAS ISFRYN (1865 - 1942), Wesleyan minister
- HUGHES, THOMAS JOHN (Adfyfr; 1853 - 1927), journalist
- HUGHES, THOMAS JONES (1822 - 1891), cleric and grammarian
- HUGHES, THOMAS MCKENNY (1832 - 1917), geologist
- HUGHES, THOMAS ROWLAND (1903 - 1949), poet and novelist
- HUGHES, VYRNWY, journalist - see HUGHES, HYWEL STANFORD
- HUGHES, WILLIAM (1757 - 1846), Independent minister, hymn-writer, and composer
- HUGHES, WILLIAM (1838 - 1921), printer and publisher
- HUGHES, WILLIAM (d. 1600), bishop of St Asaph
- HUGHES, WILLIAM (d. 1794?), clock-maker
- HUGHES, WILLIAM (1798 - 1866), harpist
- HUGHES, WILLIAM (1849 - 1920), cleric and author
- HUGHES, WILLIAM (1779 - 1836), engineer
- HUGHES, WILLIAM BULKELEY (1797 - 1882), Member of Parliament
- HUGHES, WILLIAM GRAY (d. 1824), vicar - see GREY, THOMAS
- HUGHES, WILLIAM JOHN (1833 - 1879), musician and schoolmaster
- HUGHES, WILLIAM JOHN (GARETH HUGHES; 1894 - 1965), actor
- HUGHES, WILLIAM JOHN (1891 - 1945), school teacher and college lecturer
- HUGHES, WILLIAM LEWIS Kinmel (1767 - 1852), M.P. - see HUGHES, HUGH ROBERT
- HUGHES, WILLIAM LEWIS Kinmel (1821 - 1852) - see HUGHES, HUGH ROBERT
- HUGHES, WILLIAM MELOCH (1860 - 1926), colonist and writer
- HUGHES, WILLIAM ROBERT (1798? - 1879), healer of cancer and cancerous warts
- HUGHES, WILLIAM ROGER (1898 - 1958), cleric and poet
- HUGHES, MARGARET (Leila Megáne; 1891 - 1960), singer
- HUMILIS - see JONES, JOHN
- HUMPHREY, - see LEWIS
- HUMPHREY, Llwyn-du Llangelynnin - see LEWIS
- HUMPHREYS, Caerynwch - see RICHARDS
- HUMPHREYS, BENJAMIN (1856 - 1934), Baptist minister
- HUMPHREYS, DAVID (1813 - 1866), minister (CM)
- HUMPHREYS, EDWARD MORGAN (1882 - 1955), journalist, writer and broadcaster
- HUMPHREYS, EDWARD OWEN (1899 - 1959), educationalist
- HUMPHREYS, GEORGE (1747? - 1813), sexton, poet
- HUMPHREYS, HENRY (fl. 1819-1824), harpist
- HUMPHREYS, HUGH (1817 - 1896), printer and publisher
- HUMPHREYS, HUMPHREY (1648 - 1712), bishop, antiquary, historian, and genealogist