- GRIFFITHS, ANN (1776 - 1805), hymn-writer
- GRIFFITHS, ARCHIBALD REES (1902 - 1971), painter
- GRIFFITHS, DAVID (1756 - 1834), Methodist cleric
- GRIFFITHS, DAVID (1792 - 1863), missionary
- GRIFFITHS, DAVID REES (Amanwy; 1882 - 1953), poet and writer
- GRIFFITHS, DAVID ROBERT (1915 - 1990), Baptist minister and Biblical scholar
- GRIFFITHS, EDWARD (1929 - 1995), industrial chemist and Member of Parliament
- GRIFFITHS, EDWIN STEPHEN (1868 - 1930), busnessman and philanthopist
- GRIFFITHS, ERNEST HOWARD (1851 - 1932), physicist and educationalist
- GRIFFITHS, EVAN (Ieuan Ebblig; 1795 - 1873), Independent minister
- GRIFFITHS, EVAN (1778 - 1839), Calvinistic Methodist minister
- GRIFFITHS, EVAN THOMAS (1886 - 1967), teacher, scholar and writer
- GRIFFITHS, EZER (1888 - 1962), physicist
- GRIFFITHS, GRIFFITH (1762 - 1818), Presbyterian minister
- GRIFFITHS, GRIFFITH (1799 - 1845), Anglican missionary
- GRIFFITHS, GRIFFITH PENNAR (1860 - 1918), Congregational minister
- GRIFFITHS, HENRY (1812 - 1891), Independent minister and college tutor
- GRIFFITHS, HENRY (1825 - 1886), minister - see GRIFFITHS, HENRY
- GRIFFITHS, IEUAN - see WILLIAMS, DAVID MATTHEW
- GRIFFITHS, JAMES (1782 - 1858), Independent minister
- GRIFFITHS, JAMES (JEREMIAH) (1890 - 1975), Labour politician and cabinet minister
- GRIFFITHS, JEREMIAH - see GRIFFITHS, JAMES
- GRIFFITHS, JIM - see GRIFFITHS, JAMES
- GRIFFITHS, JOHN (1837 - 1918), artist
- GRIFFITHS, JOHN (1820 - 1897), cleric and educationalist
- GRIFFITHS, JOHN (1731 - 1811), Independent minister, and schoolmaster
- GRIFFITHS, JOHN (fl. 1795), Independent minister - see GRIFFITHS, DAVID
- GRIFFITHS, JOHN GWYNEDD (1911 - 2004), scholar, poet and Welsh nationalist
- GRIFFITHS, JOHN POWELL (1875 - 1944), minister (Baptist) and schoolmaster
- GRIFFITHS, JOHN THOMAS (1824 - 1895), mining engineer
- GRIFFITHS, MORRIS (fl. 1766-1805), Methodist exhorter, afterwards Baptist minister, and hymn-writer
- GRIFFITHS, MORRIS (1721 - 1769), Independent minister
- GRIFFITHS, PETER HUGHES (1871 - 1937), Calvinistic Methodist minister and author
- GRIFFITHS, PHILIP JONES (1936 - 2008), photographer
- GRIFFITHS, RICHARD (1756 - 1826), colliery pioneer
- GRIFFITHS, ROBERT (1824 - 1903), musician
- GRIFFITHS, ROBERT (1805 - 1883), engineer and inventor
- GRIFFITHS, SAMUEL (1783 - 1860), Independent minister
- GRIFFITHS, THOMAS (JEREMY) (Tau Gimel; 1797? - 1871), Unitarian minister and schoolmaster
- GRIFFITHS, THOMAS (1645 - 1725) Delaware, first minister of the Welsh Tract Baptist church
- GRIFFITHS, VAVASOR (d. 1741), Independent minister and tutor
- GRIFFITHS, WILLIAM (1788 - 1861), Calvinistic Methodist minister
- GRIFFITHS, WILLIAM (1777 - 1825), Independent minister and teacher
- GRIFFITHS, WILLIAM (Ifander; 1830 - 1910), choral conductor and adjudicator
- GRIFFITHS, WILLIAM (1859 - 1940), Unitarian minister and Hebrew scholar
- GRIFFITHS, WILLIAM (1898 - 1962), bookseller
- GRIFFITHS, WILLIAM ALONZO (1842 - 1893), Independent minister, hymn-writer and hymnologist
- GRIFFITHS, WINIFRED MAIR (1916 - 1996), minister (Cong) and headmistress
- GRIST, IAN (1938 - 2002), Conservative politician
- GRONOW, DANIEL (d. 1796), Presbyterian minister