- GRIFFITH, GEORGE (1601 - 1666), bishop
- GRIFFITH, GEORGE WILLIAM (1584 - 1655?), landowner, attorney, magistrate, and antiquary
- GRIFFITH, GRACE WYNNE (1888 - 1963), novelist
- GRIFFITH, GRIFFITH WYNNE (1883 - 1967), minister (Presb.) and author
- GRIFFITH, GWILYM WYNNE (1914 - 1989), physician and Medical Officer of Health
- GRIFFITH, HUW WYNNE (1915 - 1993), minister (Presb) and a prominent ecumenical leader
- GRIFFITH, JAMES MILO (1843 - 1897), sculptor
- GRIFFITH, JOHN (Y Gohebydd; 1821 - 1877), newspaper correspondent, campaigner for education, and principal mover in re-establishing the Honourable Society of Cymmrodorion
- GRIFFITH, JOHN (1818? - 1885), cleric and controversialist
- GRIFFITH, JOHN (1752 - 1818), Independent minister
- GRIFFITH, JOHN (1863 - 1933), schoolmaster and musician
- GRIFFITH, JOHN (fl. 1649-1669) Llanddyfnan, squire poet
- GRIFFITH, JOHN (1713 - 1776), Quaker
- GRIFFITH, JOHN (fl. 1548-1587), civil lawyer
- GRIFFITH, JOHN (1654 - 1698), genealogist - see GRIFFITH, THOMAS TAYLOR
- GRIFFITH, JOHN (1799 - 1877), Independent minister - see GRIFFITH, JOHN
- GRIFFITH, JOHN EDWARDS (1843 - 1933), naturalist and antiquary
- GRIFFITH, JOHN OWEN (Ioan Arfon; 1828 - 1881), poet and critic
- GRIFFITH, Sir JOHN PURSER (1848 - 1938), civil engineer
- GRIFFITH, JOHN THOMAS (1845 - 1917), Baptist minister
- GRIFFITH, MORGAN WILLIAM (Pencerdd Mynwy; 1855 - 1925), musician
- GRIFFITH, MOSES (1747 - 1819), draughtsman and water-colour painter
- GRIFFITH, OWEN (Giraldus; 1832 - 1896), Baptist minister, editor and author
- GRIFFITH, OWEN (Ywain Meirion, Owen Gospiol; 1803 - 1868), ballad-writer and strolling ballad-singer
- GRIFFITH, OWEN (Eryr Eryri; 1839 - 1903), musician
- GRIFFITH, PIERS - see GRIFFITH, PIRS
- GRIFFITH, PIRS (1568 - 1628), squire and adventurer
- GRIFFITH, RICHARD (Carneddog; 1861 - 1947), poet, writer, and journalist
- GRIFFITH, RICHARD DAVIES (1813 - 1856), Wesleyan missionary and linguist
- GRIFFITH, ROBERT (1847 - 1909), musician
- GRIFFITH, ROBERT ARTHUR (Elphin; 1860 - 1936), author and lawyer
- GRIFFITH, ROBERT DAVID (1877 - 1958), musician and historian of Welsh congregational singing
- GRIFFITH, ROBERT WILLIAM (1835 - 1894), Independent minister - see GRIFFITH, DAVID
- GRIFFITH, ROGER (d. 1708), Presbyterian minister and tutor, afterwards archdeacon
- GRIFFITH, ROWLAND (fl. 18th century), harpist and harp maker
- GRIFFITH, Sir SAMUEL WALKER (1845 - 1920), judge
- GRIFFITH, THOMAS, weaver - see THOMAS, DAVID
- GRIFFITH, THOMAS TAYLOR (1795 - 1876), surgeon and antiquary
- GRIFFITH, WALTER (1727 - 1779), captain R.N.
- GRIFFITH, WALTER (1819 - 1846), advocate of free trade
- GRIFFITH, WILLIAM (1719 - 1782), farmer
- GRIFFITH, WILLIAM (1801 - 1881), Independent minister and hymn-writer
- GRIFFITH, WILLIAM (Gwilym Caledffrwd; 1832 - 1913), quarryman and musician
- GRIFFITH, WILLIAM (1704 - 1747), early Welsh Moravian (one of the original members of the London Moravian congregation)
- GRIFFITH, WILLIAM (1853 - 1918), mining engineer and author
- GRIFFITH, WILLIAM (fl. end of 16th century), admiralty judge for Caernarfonshire - see GRIFFITH, JOHN
- GRIFFITH, WILLIAM JOHN (1875 - 1931), writer of short stories
- GRIFFITH-JONES, EBENEZER (1860 - 1942), Congregational minister and college principal
- GRIFFITH-JONES, WILLIAM (1895 - 1961), Independent minister and administrator
- GRIFFITH-WYNNE, CHARLES WYNNE (d. 1865), sheriff of Caernarfonshire and Denbighshire - see GRIFFITH