- LEWIS, HUGH DAVIES (1866 - 1937), prominent in the world of insurance - see LEWIS, Sir ALFRED EDWARD
- LEWIS, HYWEL DAVID (1910 - 1992), university professor and philosopher
- LEWIS, IDRIS (1889 - 1952), musician
- LEWIS, IVOR (1895 - 1982), consultant surgeon
- LEWIS, JAMES (1674 - 1747), Independent minister
- LEWIS, JANET ELLEN (1900 - 1979), novelist, poet and journalist
- LEWIS, JENKIN (1760 - 1831), Independent minister and tutor
- LEWIS, JOHN (GOMER) (1844? - 1914), Baptist minister and orator
- LEWIS, JOHN (d. 1616?) Llynwene, Llanfihangel Nant Melan, barrister, and author of The History of Britain
- LEWIS, JOHN (Eos Glyn Wyre; 1836 - 1892), poet and musician
- LEWIS, JOHN (fl. 1646-1656) Glasgrug,, Puritan author
- LEWIS, JOHN (fl. 1728-1755), printer and publisher
- LEWIS, JOHN (1792? - 1816), Wesleyan missionary
- LEWIS, JOHN (fl. 1759-1773), Quaker and author
- LEWIS, JOHN DANIEL VERNON (1879 - 1970), scholar, Independent minister, author, tutor and theological college principal
- LEWIS, JOHN DAVID (1859 - 1914), bookseller, local historian, and founder of a printing press
- LEWIS, Sir JOHN HERBERT (1858 - 1933), lawyer and politician
- LEWIS, JOHN HUW (1931 - 2008), printer and publisher
- LEWIS, JOHN SAUNDERS (1893 - 1985), politician, critic and dramatist
- LEWIS, JOSEPH RHYS (Alaw Rhondda; 1860 - 1920), musician
- LEWIS, JOSHUA (1816 - 1879), Independent minister
- LEWIS, LEWIS (Lewsyn yr Heliwr, Lewsyn Shanco Lewis; 1793 - ?), haulier and revolutionary
- LEWIS, LEWIS WILLIAM (Llew Llwyfo; 1831 - 1901), poet, novelist, and journalist
- LEWIS, MARY ANNE - see LEWIS
- LEWIS, MATHEW (1817? - 1860), Congregational minister and writer
- LEWIS, MORGAN JOHN (c. 1711 - 1771), Methodist exhorter and hymn-writer
- LEWIS, MOSES (fl. 1748-1800), Methodist exhorter, afterwards an Antinomian
- LEWIS, OWEN (1533 - 1594), bishop of Cassano,
- LEWIS, PIERCE (1664 - 1699), cleric, and 'corrector' of the Welsh Bible of 1690
- LEWIS, REES (Eos Ebrill; 1828 - 1880), schoolmaster and musician
- LEWIS, RICHARD (Dic Penderyn; 1807/8 - 1831), miner and revolutionary martyr
- LEWIS, RICHARD (1817 - 1865), pharmacist and author
- LEWIS, RICHARD MORRIS (1847 - 1918), scholar and littérateur
- LEWIS, ROBERT EDWARD (fl. early 18th century), poet
- LEWIS, Lady RUTH (1871 - 1946), a pioneering collector of Welsh folk-songs, and advocate of educational, religious, temperance and philanthropic bodies
- LEWIS, RUTH HERBERT - see LEWIS, RUTH
- LEWIS, SAMUEL SAVAGE (1836 - 1891), classical scholar - see LEWIS, GEORGE
- LEWIS, THOMAS (1837 - 1892), Independent minister and tutor
- LEWIS, THOMAS (1823 - 1900), Baptist minister, and historical writer
- LEWIS, THOMAS (fl. 1731-1749), translator and Methodist exhorter
- LEWIS, THOMAS (1671? - 1735), Baptist minister
- LEWIS, THOMAS (1759 - 1842), hymn-writer
- LEWIS, THOMAS (fl. 18th century), hymn-writer
- LEWIS, THOMAS (1859 - 1929) Cameroons, Congo, Baptist missionary
- LEWIS, THOMAS (1868 - 1953), Principal of Brecon Memorial College
- LEWIS, Sir THOMAS (1881 - 1945), physician
- LEWIS, THOMAS (1821 - 1897), founder of a corn and flour business - see LEWIS, Sir HENRY
- LEWIS, THOMAS ARNOLD (1893 - 1952), insurance manager, treasurer of the Honourable Society of Cymmrodorion
- LEWIS, Sir THOMAS FRANKLAND (1780 - 1855), politician
- LEWIS, THOMAS PALESTINA - see LEWIS, Sir HENRY